Introduction
If you’re struggling with depression, anxiety, PTSD, or chronic pain—and traditional treatments haven’t worked—you may have heard about ketamine infusion therapy as a new option. For many, the idea of trying ketamine can bring up a mix of curiosity and hesitation. After all, ketamine is unlike most conventional treatments: it’s fast-acting, it works differently in the brain, and it has shown impressive results in patients who were previously considered treatment-resistant.
This guide is written specifically for first-time ketamine patients. We’ll walk you through what ketamine is, how the therapy works, what to expect during your session, and how to prepare for the best outcome.
What Is Ketamine?
Originally developed as an anesthetic in the 1960s, ketamine has since been approved by the FDA in multiple forms. At sub-anesthetic doses, it has powerful antidepressant, anti-anxiety, and pain-relieving properties.
Unlike traditional antidepressants that act on serotonin or dopamine, ketamine targets NMDA receptors and boosts glutamate, the most abundant excitatory neurotransmitter in the brain. This leads to rapid increases in neuroplasticity—your brain’s ability to form new, healthy connections.
Ketamine is used in two primary formats for mental health treatment:
- IV (Intravenous) Infusion Therapy: The most studied and most controllable form, administered by trained medical professionals in a clinical setting.
- Nasal Spray (Esketamine/Spravato): FDA-approved and often used in conjunction with oral antidepressants.
This guide focuses on IV infusion therapy, which is what we provide at Central Florida Ketamine.
Is Ketamine Right for You?
Ketamine therapy may be a good option if you:
- Have treatment-resistant depression
- Struggle with PTSD, anxiety, or chronic pain
- Have not responded well to conventional medications
- Are seeking a non-opioid option for pain management
- Want a faster-acting alternative to antidepressants
Each patient is thoroughly evaluated prior to beginning treatment. A full medical and psychiatric history is reviewed to ensure ketamine therapy is appropriate and safe.
What to Expect Before Your First Appointment
1. Initial Consultation
The first step is an in-depth consultation with our medical team. We’ll review your health history, current symptoms, medications, and previous treatment experiences. This ensures we tailor the infusion plan specifically to your needs.
2. Pre-Infusion Instructions
You’ll be asked to follow some guidelines before your appointment:
- Do not eat solid food within six hours of the infusion
- Clear liquids (like water) are allowed up to two hours before
- Avoid alcohol or recreational drugs 24 hours prior
- Bring a friend or family member to drive you home
During the Infusion: What Happens
The Environment
At Central Florida Ketamine, we provide a private, calm, and comfortable environment. You’ll be seated in a reclining chair, and a nurse will insert a small IV into your arm. The infusion itself typically lasts 40 to 60 minutes.
The Experience
The effects of ketamine begin gradually. Many patients describe:
- A light or floating sensation
- Changes in perception or awareness
- A sense of detachment from their surroundings or body
- Deep introspective thoughts
These effects are normal and expected. You are monitored closely by medical professionals throughout the infusion, and you can signal staff at any time if you need support.
Is It Scary?
For most patients, the experience is not frightening—just different. While some may feel a bit disoriented or emotional, others describe the session as deeply relaxing or even euphoric. Patients are often surprised at how quickly their mood or pain perception improves following treatment.
After the Infusion
Immediate Recovery
You’ll rest for about 30 minutes after the infusion to ensure you’re stable before leaving. You must have someone drive you home, as your coordination and alertness may be mildly affected for several hours.
Side Effects
Most side effects are mild and temporary. These may include:
- Nausea
- Dizziness
- Fatigue
- Mild increase in blood pressure or heart rate
Our staff is trained to manage these side effects and will check in with you throughout the process.
When Will I Feel Results?
Some patients feel a noticeable mood improvement within hours. Others may need a few sessions before results become clear. A typical treatment course involves 6 infusions over 2–3 weeks, followed by maintenance sessions as needed.
Tips to Maximize the Benefits
- Set Intentions
Before your session, reflect on your goals. Are you hoping for relief from pain? Clarity with anxiety? Emotional processing? Setting intentions helps anchor the experience. - Create a Support System
Ketamine is not a stand-alone solution. It’s most effective when paired with therapy, healthy habits, and emotional support. - Avoid Negative Influences
In the hours before and after your session, avoid stressful environments or distressing content. Give yourself space to integrate the experience. - Stay Consistent
One session can be powerful, but long-term benefits typically come with consistent treatment and maintenance protocols.
Common Questions About Ketamine Infusion Therapy
Is It Safe?
Yes. Ketamine has a long track record of safety when administered by trained professionals in a clinical setting. It is not the same as recreational ketamine use, which carries risks due to dosage, frequency, and purity concerns.
Will I Be “High”?
You may experience altered perception, but it’s not a recreational high. The effects are therapeutic and time-limited. Most patients remain aware of their surroundings throughout the infusion.
Can I Return to Work the Same Day?
It’s recommended to rest the day of your infusion. Most people return to normal activities the next day.
Is It Addictive?
In medical use, ketamine is non-addictive when administered responsibly. It is used under close supervision and never taken home.
Is It Covered by Insurance?
IV ketamine therapy is not currently covered by most insurance plans. However, we can provide documentation for out-of-network reimbursement, and payment plans may be available.
What Makes Central Florida Ketamine Different?
We combine clinical excellence with patient-centered care. Here’s what sets us apart:
- Board-certified professionals overseeing each session
- A quiet, welcoming environment for healing and reflection
- Customized treatment plans based on each patient’s diagnosis and goals
- Coordination with referring providers, therapists, or primary care teams
- Transparent pricing and upfront communication
We believe that transformative care should be accessible, compassionate, and grounded in evidence. That’s what we provide every day.
Connect With Us Today
At Central Florida Ketamine, we’re here to guide you through your healing journey—every step of the way. If you’re considering ketamine therapy and want answers, support, and clarity, we invite you to reach out.
Visit Us
Central Florida Ketamine
1120 S Park Ave
Apopka, FL 32703
Call Our Care Team
(321) 251-2240
Schedule a Confidential Consultation
Whether you’re a patient or a referring provider, we’re happy to answer your questions and help you determine whether ketamine therapy is the right path forward.
You don’t have to face this alone. Relief is closer than you think.
